Benzoic acid, 4-methoxy-3-[[[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]amino]sulfonyl]-

Benzoic acid, 4-methoxy-3-[[[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]amino]sulfonyl]-

ERAP1-IN-1

CAS: 865273-97-8

Molecular Formula: C20H21F3N2O5S

Benzoic acid, 4-methoxy-3-[[[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]amino]sulfonyl]- - Names and Identifiers

Name	ERAP1-IN-1
Synonyms	ERAP1-IN-1 4-Methoxy-3-(N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl)sulfamoyl)benzoic acid Benzoic acid, 4-methoxy-3-[[[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]amino]sulfonyl]-
CAS	865273-97-8

Benzoic acid, 4-methoxy-3-[[[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]amino]sulfonyl]- - Physico-chemical Properties

Molecular Formula	C20H21F3N2O5S
Molar Mass	458.45
Density	1.428±0.06 g/cm3(Predicted)
Boling Point	605.6±65.0 °C(Predicted)
pKa	3.88±0.10(Predicted)
Storage Condition	2-8°C，避光，干燥，密封
In vitro study	ERAP1-IN-1 (compound 3) allosterically activates ERAP1’s hydrolysis of fluorogenic and chromogenic amino acid substratesv. ERAP1-IN-1 (50 µM) exhibits specific inhibition of ERAP1 in the cellular context.

Benzoic acid, 4-methoxy-3-[[[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]amino]sulfonyl]- - Reference Information

biological activity	ERAP1-in-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor, which can competitively inhibit the effect of ERAP1 on the representative biological substrate ninthan peptide.
target	ERAP1
in vitro study	ERAP1-IN-1 (compound 3) allosterically activates ERAP1's hydrolysis of fluorogenic and chromogenic amino acid substratesv. ERAP1-IN-1 (50 µM) exhibits specific inhibition of ERAP1 in the cellular context.

Last Update：2024-04-09 21:54:55

Benzoic acid, 4-methoxy-3-[[[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]amino]sulfonyl]-

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Benzoic acid, 4-methoxy-3-[[[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]amino]sulfonyl]-

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